Bioinformatics

Dr Stuart Kauffman


Dr Stuart Kauffman
iCORE Chair, Biocomplexity and Informatics
University of Calgary

Dr Stuart Kauffman receives funding from his iCORE Chair award ($4.55M), a CFI grant ($710K) and a grant from Alberta Science and Research Investments Program ($1.1M).

Research Program Overview
The field of genetic regulatory network research is exploding in this coming decade. With the human genome spread before us, the genomes of many other organisms similarly sequenced (and others on the way) researchers have an unprecedented opportunity to establish a new quantitative science of genomics.

To understand the living state-from the perspectives of Systems Biology and non-equiliabrium thermodynamics-the areas of physics, chemistry, biology, computer science, and mathematics must be explored. Heading the iCORE Chair at the University of Calgary’s Institute for Biocomplexity and Informatics (IBI), this is exactly what Dr Stuart Kauffman does.

The IBI conducts intense, coordinated, interdisciplinary research by developing theories and companion experiments in the fields of genetic and cell regulatory networks. In doing so, the full potentials of understanding such networks can be realized for the benefit of science and human health. Most importantly, the research program focuses on cancer cell differentiation, with enormous potential application in human health.

The IBI permits Dr Kauffman and his expanding research team to launch unprecedented experimental work including high-throughput screening and image analysis of cancer cell lines to seek novel drug targets. This experimental work is taking place in concert with the theoretical, mathematical, and computer simulation by physicists, biologists, medical doctors, mathematicians, and theorists who are developing useful experimental approaches and techniques, new algorithms, models, and exploration methods.

Science policy networking continues as a major outreach thrust of the IBI, with ongoing work at local, provincial, national, and international levels, and has resulted in increased awareness and collaborative potential of the significance to understanding the relationship between the emerging “new science on the ground”, and the shaping of long-term science policy that support and help new science develop.

Biographical Information
Dr Stuart Kauffman is a professor at the University of Calgary with a shared appointment between biological sciences and physics and astronomy. He is an emeritus professor of biochemistry at the University of Pennsylvania, a MacArthur Fellow, and an external professor at the Santa Fe Institute.

Originally a medical doctor, Dr Kauffman's primary work has been as a theoretical biologist studying the origin of life and molecular organization. Dr Kauffman was the founding general partner and chief scientific officer of The Bios Group, a company (acquired in 2003 by NuTech Solutions) that applies the science of complexity to business management problems. He is the developer of the Kauffman models (random networks exhibiting a kind of self-organization that he terms "order for free"). He is the author of The Origins of Order, Investigations, and At Home in the Universe: The Search for the Laws of Self-Organization.

Related Links:
Dr Stuart Kauffman’s Homepage
Institute for Biocomplexity and Informatics (IBI)

April 28, 2005
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